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Dr K Y GOH HAEMATOLOGY & INTERNAL MEDICINE CLINIC

We listen. We Care. Evidence-based Medicine

What are stem cells ?

Stem cells are the foundation cells in our bodies. Throughout our lives, our own stem cells continuously replace injured tissues and cells that are lost everyday, such as those in our skin, hair and blood.  

Stem cells that two key properties : (1) the ability to self-renew and reproduce and (2) the ability to differentiate to different functional cell types, that make up our organs and tissues.

 

What are Mesenchymal Stem Cells (MSCs) ?

Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into a variety of cell types in the body, including bone cells, cartilage cells, fat cells and other cells in the body.

 

What can MSCs do ?

MSCs have been shown to be effective in the treatment of many diseases, including immune diseases and non-immune diseases.

 

Methods and techniques of applying MSCs

MSCs engraft into damaged tissue, for as long as 13 months after transplantation.

The transplanted MSCs could undergo site-specific differentiation into cartilage, fat, muscle, heart muscle, bone marrow cells depending on their location.

 

What are the different types of Stem Cell ?

1. Adult stem cells such as haematopoietic stem cells & mesenchymal stem cells.

2. Embryonic stem cells (ES)

3. Induced pleuripotent stem cells (iPS)

There are serious ethical concerns with ES whereas ES and iPS have potential for teratoma formation.

 

 

MSCs CAN REPAIR TISSUE INJURY:

They are responsible for growth, wound healing, replacing cells that are lost through daily wear and tear and pathological conditions.

e.g. liver cirrhosis, diabetic limb, bone damage, burn-induced skin defects, cornea damage, spinal cord injury

 

 

 

 

 

 

MSCs can be delivered by

1. Intravenous route : directing injected into the blood stream.  MSCs will "home" to the site of injury/damage

2. Direct local injection into site of injury/damage

How do MSCs look like ?

 

What is so exciting about Mesenchymal Stem Cell ?

1. free of ethical concern and teratoma formation.

2.possess self-renewal ability and can differentiate into various cell types

3.can be easily be isolated from bone marrow, adipose tissue, umbilical cord, and can be expanded in-vitro(outside the human body).

 

MSCs HAVE A POWERFUL CAPACITY IN REGULATING IMMUNE REPONSES such as

1. treatment of graft-versus-host-disease in patients receiving bone marrow/stem cell transplantation

2, Systemic Lupus Erythematosus, Crohn's disease